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Compared with all-atom force fields, early coarse-grained (CG) models were once considered as "toys" to study qualitative properties of biophsical processes such as protein folding. However, as people's interest increases in large-scale biological phenomenons, such as genome organization, liquid-liquid phase separation, and virus capsid assembly, CG models begin to show their advantage in lower computational cost. On the other hand, recent development of the CG models also gained great success in improving the accuracy. We first review the advances of the latest CG models for protein, DNA, and RNA. We then describe the currenet progress of the implementation of these models in the MD software GENESIS. At last, we show some simple applications of the CG simulations with GENESIS.