The 183rd R-CCS Cafe - part 3

The human brain is estimated to include about 100 billion neurons and 100 trillion connections. A whole-brain simulation helps us to investigate all interactions between neurons for elucidating brain function and disease. However, a human-scale whole-brain simulation has not been realized due to the lack of sufficient computational resources in the current supercomputers and experimental data for modeling.
In the project of Exploratory Challenge on post-K computer #4-1, to realize human-scale whole-brain simulation on the Fugaku computer, we have been constructing a mammalian whole-brain model consisting of the cerebral cortex, thalamus, cerebellum, and basal ganglia using NEST simulator, and developing an in-house simulator specialized for the whole brain-simulation on the next-generation supercomputers.
In the first part of the presentation, we are going to introduce simulation studies on modulation of a network state by a hierarchical inhibitory circuitry in the primary motor cortex, and neural responses to different spatial size signals in the primary somatosensory cortex. In the second part, we are going to present studies on one-third of human-scale cortical simulation and a full of human-scale cerebellar simulation on the K computer. Finally, we are going to present our future perspective of large-scale brain simulations on Fugaku computer based on the current result in our project.