トップページ
イベント・広報
R-CCS Cafe
R-CCS Cafe 第284回(2026年1月23日)
R-CCS Cafe 第284回(2026年1月23日)
English| 開催日 | 2026年1月23日(金) |
|---|---|
| 開催時間 | 15:00 - 16:00(15:00 - 15:40 講演者2名による講演、15:40~ 自由討論(参加自由)) |
| 開催都市 | 兵庫県神戸市/オンライン |
| 場所 | 計算科学研究センター(R-CCS)6階講堂/Zoomによる遠隔セミナー
|
| 使用言語 | 発表・スライド共に英語 |
| 登壇者 |
Cheng Tan 粒子系生物物理研究チーム ![]() Yuki Miyazaki 量子系物質科学研究チーム ![]() |
講演題目・要旨
1st Speaker: Cheng Tan
Title:
Modulation of Biomolecular Condensates Studied by Multi-Scale Molecular Dynamics Simulations
Abstract:
Biomolecules such as intrinsically disordered proteins form dynamic condensates through highly entangled networks of weak interactions. Although extensive research has elucidated their formation mechanisms, how these condensates are regulated to prevent aggregation remains unclear. Using large-scale all-atom molecular dynamics simulations (~2.5 million atoms, Fugaku), we studied TDP-43 condensates and their regulation by the highly charged protein Hero11. Hero11 reduces condensate density, increases fluidity and ion influx, and alters water dynamics. It modulates protein diffusion and promotes coupling between reduced intermolecular contacts and decreased α-helical propensity in TDP-43’s C-terminal domain, revealing mechanisms of condensate regulation.
2nd Speaker: Yuki Miyazaki
Title:
Studying one-dimensional quantum criticality via sine-square deformation
Abstract:
Sine-square deformation (SSD) is a smooth boundary modulation in which the local energy scale of the Hamiltonian is modulated by a site-dependent function, efficiently suppressing boundary effects under open boundary conditions. In this talk, we propose a method to analyze quantum critical phenomena in one-dimensional systems, based on the theoretical expectation that translational invariance of local observables in the ground state of the SSD Hamiltonian is restored at quantum critical points (QCPs). As case studies, we demonstrate our procedure using two models: the antiferromagnetic Ising chain in mixed transverse and longitudinal magnetic fields with nearest-neighbor and long-range interactions. For the nearest-neighbor model, we show that the QCP can be accurately estimated by our procedure with systems of up to 84 sites, or even smaller, in good agreement with results from the literature. For the long-range model, we show that our method also allows us to determine the phase boundary, which is found to be slightly shifted relative to the nearest-neighbor case, leading to a reduced region of antiferromagnetic order. We further examine whether this framework can be extended beyond locating QCPs to characterize critical phenomena. Our results suggest that the SSD-based framework may be useful for extracting critical exponents and analyzing scaling behavior in quantum systems.
Moreover, we propose an experimental scheme to implement the antiferromagnetic $J_1-J_2$ Ising couplings with SSD using Rydberg atom arrays in optical tweezers to a very good approximation.
注意事項
- 参加の際はPCマイクの音声・ビデオをオフにされるようお願いいたします。
- 当日の会場環境や通信状態により、やむなく配信を中止・中断する場合がございます。
- プログラムの内容、時間は予告なく変更される場合があります。
- ご使用の機器やネットワークの環境によっては、ご視聴いただけない場合がございます。
- インターネット中継に関する著作権は、主催者及び発表者に帰属します。なお、配信された映像及び音声、若しくはその内容を、理化学研究所の許可無くほかのウェブサイトや著作物等への転載、複製、改変等を行うことを禁じます。
(2026年1月19日)


